The active substance is vardenafil. It is used orally to improve erection in men with erectile dysfunction. In natural conditions, i.e. with sexual arousal, vardenafil restores erectile function as a result of increased blood flow to the penis. Penile erection is a hemodynamic process. Nitric oxide is released during sexual arousal. This compound activates the enzyme guanyl cyclase, which leads to an increase in the concentration of cyclic guanosine monophosphate (cGMP) in the cavernous bodies. This in turn causes smooth muscle relaxation to allow more blood flow to the penis. The concentration of cGMP depends on the rate of its synthesis with the participation of guanyl cyclase and on the rate of its degradation by the hydrolyzing cGMP phosphodiesterase (PDE). Vardenafil strongly and selectively blocks phosphodiesterase 5 (PDE5) specific for cGMP. Therefore, it inhibits the breakdown of cGMP and increases its concentration in this way. Vardenafil significantly enhances the effects of endogenous nitric oxide on corpora cavernosa due to PDE5 inhibition. When nitric oxide is released as a result of sexual arousal, inhibition of PDE5 by vardenafil causes an increase in cGMP in the corpus cavernosum. Sexual arousal is necessary for beneficial therapeutic effects of vardenafil. Vardenafil causes a mild and transient decrease in blood pressure, which in most cases is not clinically significant. The preparation is quickly absorbed after oral administration, reaching a maximum concentration in the blood after 30-120 minutes. Penetrates into tissues, is 95% bound to plasma proteins. It is mainly excreted in the form of metabolites, mainly in the faeces (91–95% of the dose), with a small proportion in the urine.
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At O'Reilly, we assume that most people are intelligent and well-intended, and we're not inclined to tell people what to do. However, we want every O'Reilly conference to be a safe and productive environment for everyone. To that end, this code of conduct spells out the behavior we support and don't support at conferences. The core of our approach is this:

We don't condone harassment or offensive behavior, at our conference venues or anywhere. It's counter to our company values. More importantly, it's counter to our values as human beings.

We're voicing our strong, unequivocal support of appropriate behavior by all participants at technical events, including all O'Reilly events. This applies to our events we do with event partners, such as Google and Intel. We invite you to help us make each O'Reilly conference a place that is welcoming and respectful to all participants, regardless of race, gender, gender identity and expression, age, sexual orientation, disability, physical appearance, national origin, ethnicity, or religion. So that everyone can focus on the conference itself, and the great networking and community richness that happens when we get together in person, we will not tolerate harassment of conference participants in any form—in person or online.

Examples of harassment include offensive comments, verbal threats or demands, sexualized images in public spaces, intimidation, stalking, harassing photography or recording, sustained disruption of sessions or events, and unwelcome physical contact or sexual attention. Harassment also includes slights and negative messages, both unintended and intentional, based solely on appearance (sometimes called microaggressions).

We expect all participants—attendees, speakers, sponsors, and volunteers—to follow the Code of Conduct during the conference. This includes conference-related social events at off-site locations, and in related online communities and social media. Participants asked to stop any harassing behavior are expected to comply immediately. Conference participants violating this Code of Conduct may be expelled from the conference without a refund, and/or banned from future O'Reilly events, at the discretion of O'Reilly Media.

Please bring any concerns to the immediate attention of the event staff, or contact our VP of Conferences, Gina Blaber at [email protected]. You may also call +1 617-499-7500 or fill out this form to report violations. We thank our participants for your help in keeping the event welcoming, respectful, and friendly to all.

Read the blog post by Tim O'Reilly that is the basis of our functional code of conduct for all O'Reilly conferences.

Thanks to the Lean Startup folks and the folks, whose Codes of Conduct inspired some changes to our own.

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